获重庆市自然科学一等奖1项，先后主持7项国家自然科学基金研究课，发明专利2件。在JBC、AJP和Hepatology发表论文11篇。主要发表论文如下：
1.Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL. Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.Am J Physiol Gastrointest Liver Physiol 2007,292(5):G1221-7 IF:3.761 2.Jiang H, Chen K, He J, Pan F, Li J, Chen J, Chen W Liang H.J Gastrointest Surg 2009,13(10):1831-8.IF: 2.402 3. Chai J, Luo D, Wu X, Wang H, He Y, Li Q, Zhang Y, Chen L, Peng ZH, Xiao T, Wang R, Chen W. Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis.J Gastrointest Surg 2011,15(6):996-1004.IF: 2.826 4.Chai J, He Y, Cai SY, Jiang Z, Wang H, Li Q, Chen L, Peng Z, He X, Wu X, Xiao T, Wang R, Boyer L, Chen W. Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway. Hepatology 2012,55(5):1485-94.IF: 12.003 5. Li LM，Chen L, Deng GH, Tan WT, Dan YJ, Wang RQ, Chen WS. SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury.Mol Med Rep 2012,6(1):75-82.IF: 0.418 6. Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He Y, Chen L, Wang R, Wang H, Boyer L, Chen W.Journal of Hepatology 2015. Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. IF: 11.336 7. Chai J, Du X, Chen S, Feng X, Cheng Y, Zhang L, Gao Y, Li S, He X, Wang R, Zhou X, Yang Y, Luo W, Chen W. Oral administration of oleanolic acid, isolated from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats.Int J Clin Exp Med 2015,8(2):1691-702.IF: 1.422 8. Chai J, Feng X, Zhang L, Chen S, Cheng Y, He X, Yang Y, He Y, Wang H, Wang R, Chen W. Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction. PLoS One 2015,10(3):e120055.IF: 3.234 9. Liu XC, Lian W, Zhang LJ, Feng XC, Gao Y, Li SX, Liu C, Cheng Y, Yang L, Wang XJ, Chen L, Wang RQ, Chai J, Chen WS. Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells. PoLS One 2015,10(8):e0136215. IF: 3.234，。 10. Feng XC, Du X, Chen S, Yue D, Cheng Y, Zhang L, Gao Y, Li S, Chen L, Peng Z, Yang Y, Luo W, Wang R, Chen W, Chai J. Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in ratsInt J Clin Exp Pathol. 2015，8(1):184-95. eCollection 2015.IF: 1.896， 11. Zhang L, Cheng Y, Du X, Chen S, Feng X, Gao Y, Li S, Liu L, Yang M, Chen L, Peng Z, Yang Y, Luo W, Wang R, Chen W, Chai J. Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats. Evid Based Complement Alternat Med. 2015;2015:948376 IF:1.880 |