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美国纽约州立大学石溪分校分子遗传学和微生物学系助理教授纵微星博士学术讲座
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  科室动态-->>>肿瘤科 更新时间:2010-01-29
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美国纽约州立大学石溪分校分子遗传学和微生物学系助理教授纵微星博士学术讲座的通知

 

应我院肿瘤科邀请,美国纽约州立大学石溪分校 (State University of New York at Stony Brook) 分子遗传学和微生物学系助理教授纵微星博士将来我院作学术报告,欢迎广大科技人员参加!

 

报告题目: Targeting multiple cell death pathways for cancer treatment

报告时间: 2010 1 29 ( 周五 )  15:00

报告地点:西南医院肿瘤放疗中心会议室

主持人:梁后杰 教授

 

纵微星博士简介:

纵微星博士目前为美国纽约州立大学石溪分校分子遗传学和微生物学系助理教授。长期从事肿瘤发生和治疗过程中细胞凋亡的分子机制研究。担任 Apoptosis, British J Cancer, Cancer Res, Carcinogenesis, Cell Death Differ, Clin Cancer Res, Dev Cell, FEBS Lett, Gynecol Oncol, J Biol Chem, J Cell Biol, J Clin Invest, J Exp Med, Mol Cancer Ther, Mol Cell Biol, Nat Rev Cancer, Oncogene, Proc Natl Acad Sci USA, Trends Biochem Sci 等多种专业学术杂志的审稿人,并担任 “Breast Cancer Research Program” 等项目评审专家,曾获美国 NIH Howard Temin 奖、 Susan G. Komen for the Cure 奖等 。在 Cell, Science, Nat Cell Biol, Genes Dev, PNAS, JBC 等国际有影响的杂志发表论文 43 篇,总影响因子超过 340 分,被引用 5500 余次;其中通讯作者和第一作者文章 IF 150 分,被引用 3100 余次。代表论著 Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death 单篇被引超过 1800 次;另一论著 “BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak” 单篇被引 520 次。

 

代表性论文:

1         Fan, Y., Dickman, K., and Zong, W. X. (2009). Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem. Epub ahead of print

2         Gruber J, Yong J, Zatechka DS, Sabin L, Zhang Z, Lum JJ, Kong M, Zong WX, Lau CK, Cherry S, Ihle J, Dreyfuss G, and Thompson CB. 2009. Ars2 links the nuclear cap binding complex to RNA interference and cell proliferation. Cell 138: 328-339.

3         Guerriero, J. L., Ditsworth, D., Fan, Y., Zhao, F., Crawford, H. C., and Zong, W. X. (2008). Chemotherapy induces tumor clearance independent of apoptosis. Cancer Res68, 9595-9600

4         Ricci, M. S., and Zong, W. X. (2006). Chemotherapeutic approaches for targeting cell death pathways. Oncologist11, 342-357

5         Rathmell JC, Lindsten T, Zong WX, Cinalli RM, and Thompson CB. 2002. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol 3, 932-939.

6         Ullman, E., Fan, Y., Stawowczyk, M., Chen, H. M., Yue, Z., and Zong, W. X. (2008). Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ 15, 422-425

7         Wei, M. C., Zong, W. X. (contributed equally), Cheng, E. H., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., and Korsmeyer, S. J. (2001). Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science292, 727-730

8         Zong, W. X. , Bash, J., and Gelinas, C. (1998). Rel blocks both anti-Fas- and TNF alpha-induced apoptosis and an intact Rel transactivation domain is essential for this effect. Cell Death Differ 5, 963-972

9         Zong, W. X. , Ditsworth, D., Bauer, D. E., Wang, Z. Q., and Thompson, C. B. (2004). Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18, 1272-1282

10     Zong, W. X. , Edelstein, L. C., Chen, C., Bash, J., and Gelinas, C. (1999). The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev 13, 382-387

11     Zong, W. X. , Farrell, M., Bash, J., and Gelinas, C. (1997). v-Rel prevents apoptosis in transformed lymphoid cells and blocks TNFalpha-induced cell death. Oncogene 15, 971-980

12     Zong, W. X. , Li, C., Hatzivassiliou, G., Lindsten, T., Yu, Q. C., Yuan, J., and Thompson, C. B. (2003). Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162, 59-69

13     Zong, W. X. , Lindsten, T., Ross, A. J., MacGregor, G. R., and Thompson, C. B. (2001). BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15, 1481-1486

14     Zong, W. X. , and Thompson, C. B. (2006). Necrotic death as a cell fate. Genes Dev 20, 1-15

 
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